Faculty Research 1990 - 1999
Synapsis and obligate recombination between the sex chromosomes of male laboratory mice carrying the Y* rearrangement.
Document Type
Article
Publication Date
1991
Keywords
Male, Meiosis: ge, Mice, Mice-Inbred-Strains, Microscopy-Electron, Recombination-Genetic: ge, Sex-Chromosome-Abnormalities: ge, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, X-Chromosome, Y-Chromosome: ul
First Page
231
Last Page
239
JAX Source
Cytogenet Cell Genet 1991;57(4):231-9
Grant
GM20919, RR01183, HD07065
Abstract
The synaptic and recombinational behavior of the sex chromosomes in male laboratory mice carrying the Y* rearrangement was analyzed by light and electron microscopy. Examination of zygotene and pachytene X-Y* configurations revealed a surprising paucity of the staggered pairing configuration predicted from the distal position of the X pseudoautosomal region and the subcentromeric position of the Y* pseudoautosomal region. When paired at pachynema, the X and Y* chromosomes usually assumed configurations similar to those of typical sex bivalents from normal male laboratory mice. The X and Y* chromosomes were present as univalents in more than half of the early- and mid-pachytene nuclei, presumably as a result of steric difficulties associated with homologous alignment of the pseudoautosomal regions. When paired at diakinesis and metaphase I, the X and Y* chromosomes exhibited an asymmetrical chiasmatic association indicative of recombination within the staggered synaptic configuration. Both pairing disruption and recombinational failure apparently contribute to diakinesis/metaphase I sex-chromosome univalency, as most cells at these stages possessed X and Y* univalents lacking evidence of prior recombination. Recombinant X or Y* chromosomes were detected in all metaphase II complements examined, thus substantiating the hypothesis that X-Y recombination is a prerequisite for the normal progression of male meiosis.
Recommended Citation
Hale DW,
Hunt PA,
Tucker PK,
Eicher EM.
Synapsis and obligate recombination between the sex chromosomes of male laboratory mice carrying the Y* rearrangement. Cytogenet Cell Genet 1991;57(4):231-9