Faculty Research 1990 - 1999
Mapping anti-m:ullerian hormone (Amh) and related sequences in the mouse: identification of a new region of homology between MMU10 and HSA19p.
Document Type
Article
Publication Date
1991
Keywords
Chromosome-Mapping, Chromosomes-Human-Pair-19, Crosses-Genetic, Female, Genes-Structural, Genetic-Markers, Growth-Inhibitors: ge, Human, Male, Mice: ge, Mice-Inbred-Strains, Morphogenesis: ge, Mullerian-Ducts: em, Muridae: ge, Restriction-Fragment-Length-Polymorphisms, Sequence-Homology-Nucleic-Acid, SUPPORT-U-S-GOVT-P-H-S, Testicular-Hormones: ge, Transforming-Growth-Factor-beta: ge
First Page
273
Last Page
283
JAX Source
Genomics 1991 Oct;11(2):273-83
Grant
GM20919, CA09217
Abstract
A panel of 78 backcross progeny, BALB/cJ x (BALB/cJ x CAST/Ei)F1, was used to map the gene encoding anti-M:ullerian hormone (Amh), also called M:ullerian inhibiting substance, to mouse Chromosome 10 (MMU10). This analysis identified a new region of linkage homology between human Chromosome 19p (HSA 19p) and MMU10 and localized an apparent recombinational hot spot in (C57BL/6J x Mus spretus)F1 females [compared with (BALB/cJ x CAST/Ei)F1 males] to the interval between phenylalanine hydroxylase (Pah) and mast cell growth factor (Mgf). In addition, eight unlinked polymorphic sequences, provisionally designated Amh-related sequences (Amh-rs1 through Amh-rs8), were identified by Southern blot analysis using Amh probes. Amh-rs1, -rs2, -rs4, and -rs7 were mapped to MMU1, 13, 12, and 15, respectively, by recombinant inbred (RI) strain and intraspecific backcross analyses. The NXSM RI strain distribution patterns for the four unmapped loci are also presented.
Recommended Citation
King TR,
Lee BK,
Behringer RR,
Eicher EM.
Mapping anti-m:ullerian hormone (Amh) and related sequences in the mouse: identification of a new region of homology between MMU10 and HSA19p. Genomics 1991 Oct;11(2):273-83