Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog).

Authors

T Sugisaki
W G. Beamer
T Noguchi

Document Type

Article

Publication Date

1992

Keywords

Brain: ab, Cell-Division: ph, Disease-Models-Animal, Goiter: cn, pp, pa, Mice, Mice-Mutant-Strains, Microcephaly: et, pa, Motor-Activity: ph, Myelin-Sheath: ph, Neuroglia: cy, SUPPORT-NON-U-S-GOVT

First Page

1037

Last Page

1040

JAX Source

Neurochem Res 1992 Oct;17(10):1037-40

Abstract

2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the congenital goiter mouse (cog/cog) is reduced in comparison with the normal heterozygote (cog/+). The weight of the cog/cog cerebrum and cerebellum were significantly less than those of the normal controls, 89.0% less for the cerebrum, and 81.1% less for the cerebellum. However, no differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the congenital goiter mouse is restricted to the cerebrum, and is not related to arrested glial proliferation.

Recommended Citation

Sugisaki T, Beamer WG, Noguchi T. Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog). Neurochem Res 1992 Oct;17(10):1037-40