Faculty Research 1990 - 1999

Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses.

Document Type

Article

Publication Date

1990

Keywords

Disease-Models-Animal, Mice, Mice-Mutant-Strains: ge, Models-Genetic, Skin-Diseases: ge, pa, Support-Non-U, S, -Gov't, Support-U, S, -Gov't-P, H, S

First Page

62

Last Page

63

JAX Source

J Invest Dermatol 1990 Nov; 95(5):62S-63S.

Grant

CA20408

Abstract

Nearly 100 mouse mutations have been described as causing some type of abnormality of the skin or hair. As only a few of these mutations have been studied in detail, they remain an untapped resource for furthering knowledge of basic cutaneous physiology and understanding the pathophysiology of analogous diseases in humans. Several diverse murine mutations are discussed. These include "asebia,: a mildly hyperkeratotoic disorder with sebaceous gland hypoplasia; "ichthyosis,: an example of abnormal hair growth associated with hyperkeratosis; "rhino: and "hairless,: two related examples of congenital follicular malformations; and "flaky skin:, a potential animal model of eruptive psoriasis.

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