Faculty Research 1990 - 1999

Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice.

Document Type

Article

Publication Date

1992

Keywords

Antigen-Presenting-Cells: im, Autoimmune-Diseases: ge, im, Diabetes-Mellitus-Experimental: ge, im, Diabetes-Mellitus-Insulin-Dependent: ge, im, Haplotypes, Human, Immunogenetics, Macrophages: im, Major-Histocompatibility-Complex, Mice, Mice-Inbred-NOD, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

First Page

263

Last Page

273

JAX Source

Reg Immunol 1992 Sep-Oct;4(5):263-73

Grant

DK36175/DK/NIDDK, DK27722/DK/NIDDK

Abstract

Genetically-controlled defects in the development and function of antigen presenting cells may explain why NOD mice exhibit an impaired ability to induce tolerance and/or activate immunoregulatory T cells. These defects provide understanding for why diabetogenesis in NOD mice is so sensitive to immunomodulatory changes mediated through the environment. Although the unique MHC haplotype of NOD mice is clearly a major contributor to diabetes susceptibility, evidence for a complex interaction between MHC loci and many other polygenetic factors is reviewed.

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