Faculty Research 1990 - 1999
Title
Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice.
Document Type
Article
Publication Date
1992
Keywords
Antigen-Presenting-Cells: im, Autoimmune-Diseases: ge, im, Diabetes-Mellitus-Experimental: ge, im, Diabetes-Mellitus-Insulin-Dependent: ge, im, Haplotypes, Human, Immunogenetics, Macrophages: im, Major-Histocompatibility-Complex, Mice, Mice-Inbred-NOD, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
263
Last Page
273
JAX Source
Reg Immunol 1992 Sep-Oct;4(5):263-73
Grant
DK36175/DK/NIDDK, DK27722/DK/NIDDK
Abstract
Genetically-controlled defects in the development and function of antigen presenting cells may explain why NOD mice exhibit an impaired ability to induce tolerance and/or activate immunoregulatory T cells. These defects provide understanding for why diabetogenesis in NOD mice is so sensitive to immunomodulatory changes mediated through the environment. Although the unique MHC haplotype of NOD mice is clearly a major contributor to diabetes susceptibility, evidence for a complex interaction between MHC loci and many other polygenetic factors is reviewed.
Recommended Citation
Leiter, E H. and Serreze, D V., " Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice." (1992). Faculty Research 1990 - 1999. 309.
https://mouseion.jax.org/stfb1990_1999/309