Faculty Research 1990 - 1999
Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents.
Document Type
Article
Publication Date
1992
Keywords
Disease-Models-Animal, Female, Human, Male, Mice, Mice-SCID: ps, Microfilaria: ph, Onchocerca: ph, Onchocerciasis: ps, Rats, Rats-Nude: ps, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
160
Last Page
163
JAX Source
J Parasitol 1992 Feb;78(1):160-3
Grant
R22AI27773/AI/NIAID, R01AI30389/AI/NIAID, R22AI30046/AI/NIAID
Abstract
Onchocerca volvulus is an obligate human parasite, and its study has been difficult due to an inability to maintain it outside the human host. We report the successful transplantation of onchocercomata containing living adult O. volvulus worms into immunodeficient C.B.-17.scid/scid (scid) mice or athymic rnu/rnu (nude) rats. Living, motile worms containing viable microfilariae were present in onchocercomata recovered from scid mice or nude rats for up to 20 wk, establishing a novel animal model for future investigation of O. volvulus.
Recommended Citation
Rajan TV,
Nelson FK,
Cupp E,
Schultz LD,
Greiner DL.
Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents. J Parasitol 1992 Feb;78(1):160-3