Faculty Research 1990 - 1999
Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes.
Document Type
Article
Publication Date
1992
Keywords
Chromosome-Mapping, Chromosomes-Human-Pair-4, Human, Huntington's-Disease: ge, Iduronidase: ge, Linkage-(Genetics): ge, Mice, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
23
Last Page
27
JAX Source
Mamm Genome 1992;3(1):23-7
Grant
HD21355/HD/NICHD, HG00169/HG/NCHGR, HG00189/HG/NCHGR
Abstract
alpha-L-iduronidase (IDUA), which when deficient causes mucopolysaccharidosis type I, is located near the Huntington disease locus (HD) on human Chromosome (Chr) 4p16.3, approximately 10(6) base pairs (bp) from the telomere. As part of our continuing efforts to define a detailed comparative map for this chromosomal segment in mice and humans, we have used an interspecific backcross between C57BL/6J and an inbred strain derived from Mus spretus to map Idua, the mouse homolog of IDUA. We also mapped the mouse homolog of D4S115, an anonymous locus approximately 250 kb proximal to IDUA. As expected, both Idua and D4S115h are located on the proximal portion of mouse Chr 5 near homologs for other loci on human Chr 4p. Comparison of gene order in mice and humans demonstrates, however, that a chromosomal rearrangement within this conserved synteny has occurred since divergence of lineages leading to mice and humans.
Recommended Citation
Koizumi T,
MacDonald M,
B:ucan M,
Hopwood JJ,
Morris CP,
Scott HS,
Gusella JF,
Nadeau JH.
Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes. Mamm Genome 1992;3(1):23-7