Faculty Research 1990 - 1999
Selective breeding for alcohol preference and associated responses.
Document Type
Article
Publication Date
1993
Keywords
Alcoholism: ge, pp, pa, Animal, Genetic-Markers: ge, Models-Genetic, Neurotransmitters: ph, Rats, Rats-Wistar, Selection-(Genetics), Species-Specificity
First Page
163
Last Page
170
JAX Source
Behav Genet 1993 Mar;23(2):163-70
Abstract
Selective breeding for high and low alcohol-drinking preference has produced rat lines useful for studying the nature of excessive alcohol-seeking behavior. Compared with the alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-dose activating effects of ethanol as well as enhanced capacity for developing tolerance to the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower brain serotonin and dopamine neurotransmitter activity as well as differences in other neurotransmitter neuromodulator systems, compared with the alcohol-nonpreferring animals.
Recommended Citation
Li TK,
Lumeng L,
Doolittle DP.
Selective breeding for alcohol preference and associated responses. Behav Genet 1993 Mar;23(2):163-70