Faculty Research 1990 - 1999
Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease.
Document Type
Article
Publication Date
1994
Keywords
Diabetes-Mellitus-Insulin-Dependent: ge, Disease-Models-Animal, Human, Immunotherapy: mt, Mice, Mice-Inbred-NOD, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
115
Last Page
120
JAX Source
Immunol Today 1994 Mar;15(3):115-20
Abstract
The prevention of insulin-dependent diabetes (IDD) in humans remains an elusive goal, despite the broad spectrum of therapeutic interventions that prevent the development of IDD in the non-obese diabetic (NOD) mouse. Can an animal model in which spontaneous autoimmune pathology is interrupted so easily serve as an archetype for the design of clinical trials aimed at the prevention of IDD in humans? In this article, Mark Bowman, Edward Leiter and Mark Atkinson review the intervention strategies that prevent IDD in the NOD mouse and indicate why these studies may well be relevant to the prevention of IDD in humans.
Recommended Citation
Bowman MA,
Leiter EH,
Atkinson MA.
Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today 1994 Mar;15(3):115-20