Faculty Research 1990 - 1999
Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice.
Document Type
Article
Publication Date
1994
Keywords
B-Lymphocytes: im, cy, Cell-Division: ge, Estrogen-Replacement-Therapy, Estrogens: df, ph, tu, Female, Gonadorelin: ge, Hypogonadism: dt, ge, im, Interleukin-7: ph, Mice, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
717
Last Page
720
JAX Source
J Exp Med 1994 Aug 1;180(2):717-20
Grant
AI20069/AI/NIAID, AI30389/AI/NIAID, CA20408/CA/NCI
Abstract
Interleukin 7 (IL-7) responsive B lineage precursors were greatly expanded in genetically hypogonadal female (HPG/Bm-hpg/hpg) mice that have a secondary deficiency in gonadal steroidogenesis. Estrogen replacement in these mice resulted in a dose-dependent reduction in B cell precursors. More modest increases were documented in genetically normal mice that were surgically castrated. These findings complement other recent observations that B lymphopoiesis selectively declines in pregnant or estrogen-treated animals. Sex steroids have long been known to influence such disparate processes as bone physiology and tumor growth, in addition to their importance for reproductive function. We now show that these hormones are important negative regulators of B lymphopoiesis.
Recommended Citation
Smithson G,
Beamer WG,
Shultz KL,
Christianson SW,
Shultz LD,
Kincade PW.
Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice. J Exp Med 1994 Aug 1;180(2):717-20