Faculty Research 1990 - 1999
Mice homozygous for a null mutation of activin beta B are viable and fertile.
Document Type
Article
Publication Date
1994
First Page
43
Last Page
51
JAX Source
Mech Dev 1994 Jul;47(1):43-51
Abstract
We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the homozygous mutant animals are born with open eyes. Aside from the incompletely penetrant eye defects, histopathological analysis has not revealed any other abnormalities in homozygous mutant animals. Breeding tests have shown that both male and female homozygous mutant animals are fertile.
Recommended Citation
Schrewe H,
Gendron MM,
Harbison ML,
Gridley T.
Mice homozygous for a null mutation of activin beta B are viable and fertile. Mech Dev 1994 Jul;47(1):43-51