Faculty Research 1990 - 1999
The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells.
Document Type
Article
Publication Date
1994
Keywords
Antigen-Presenting-Cells, Mice, Mice-Inbred-C3H", Superantigens, Support-Non-U, S, -Gov't", Support-U, S, -Gov't-P, H, S, ", T-Lymphocytes, Viral-Envelope-Proteins
First Page
439
Last Page
446
JAX Source
J Exp Med 1994 Feb; 179(2):439-46.
Abstract
Transgenic mice expressing either the mouse mammary tumor virus (MMTV) superantigen gene (sag) alone or in combination with the viral envelope genes (env) (LEL), or all of the viral genes (gag, pol, env, and sag) (HYB PRO), deleted V beta 14+ T cells from their immune repertoire. However," only LEL or HYB PRO transgenic antigen-presenting cells were capable of stimulating a proliferative response from nontransgenic primary T cells or interleukin 2 production from a V beta 15-bearing T cell hybridoma. These T cell responses could be inhibited by a monospecific antibody directed against the MMTV gp52 cell surface glycoprotein. These results indicate that the MMTV gp52 gene product participates in the presentation of superantigen to T cells, resulting in their stimulation, a requisite step" in the MMTV infection pathway. Thus, gp52 could play a role in the" transfer of virus between different subsets of lymphocytes.
Recommended Citation
Golovkina TV,
Chervonsky A,
Prescott JA,
Janeway CA,
Ross SR.
The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells. J Exp Med 1994 Feb; 179(2):439-46.