Faculty Research 1990 - 1999
Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19 that causes motor neuron degeneration.
Document Type
Article
Publication Date
1995
Keywords
Chromosome-Mapping: mt, Crosses-Genetic, Female, Glycogen-Phosphorylase: ge, Male, Mice, Mice-Inbred-CBA, Mice-Inbred-C57BL, Motor-Neurons: ph, pa, Muscle-Skeletal: pa, Muscular-Atrophy-Spinal: ge, pa, Mutation: ge, Nerve-Degeneration: ge, Nerve-Growth-Factors: ge, Nerve-Tissue-Proteins: ge, Spinal-Cord: pa, SUPPORT-U-S-GOVT-P-H-S
First Page
187
Last Page
191
JAX Source
Mamm Genome 1995 Mar;6(3):187-91
Grant
RR01183/RR/NCRR, GM46697/GM/NIGMS, CA34196/CA/NCI
Abstract
Neuromuscular degeneration, nmd, is a spontaneous autosomal recessive mutation in the mouse producing progressive hindlimb impairment caused by spinal muscular atrophy. We used an intersubspecific intercross between B6.BKs-nmd2J/+ and Mus musculus castaneus (CAST/Ei) to map the nmd mutation to mouse Chromosome (Chr) 19 with the most likely gene order: nmd-(D19Sel2, Pygm)-Cntf-Pomc2-D19Mit16-Cyp2c-Got1. nmd maps near muscle deficient, mdf, and has a very similar clinical phenotype, but allele tests and histological differences suggest that nmd is a distinct mutation at a different locus. Although closely linked, nmd recombined with the candidate genes muscle glycogen phosphorylase, Pygm, and ciliary neurotrophic factor, Cntf.
Recommended Citation
Cook SA,
Johnson KR,
Bronson RT,
Davisson MT.
Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19 that causes motor neuron degeneration. Mamm Genome 1995 Mar;6(3):187-91