Faculty Research 1990 - 1999
A curly-tail modifier locus, mct1, on mouse chromosome 17.
Document Type
Article
Publication Date
1995
First Page
719
Last Page
724
JAX Source
Genomics 1995 Oct 10;29(3):719-24
Grant
HD28882/HD/NICHD
Abstract
The major gene for neural tube defects, ct, in the curly-tail (CT) mouse strain was mapped previously to mouse chromosome 4 by combining linkage data from several backcrosses. The penetrance of the neural tube trait, already incomplete in the CT strain, was further reduced in several of these backcrosses, suggesting the existence of recessive modifiers or strain-specific susceptibility alleles. Here we describe the mapping of a curly-tail modifier locus, mct1, to chromosome 17 in moderate and low penetrance crosses of CT with BALB/cByJ and Mus spretus. No effect of mct1 was seen in a higher penetrance cross with the BXD-8/Ty strain, confirming that ct is the major gene in the model. Homozygosity at both ct and mct1 loci was sufficient to account for all of the affected individuals in the BALB/cByJ cross and most of the affected individuals in the M. spretus cross and was the preferred model overall. No evidence was found for epistatic interaction between ct and mct1.
Recommended Citation
Letts VA,
Schork NJ,
Copp AJ,
Bernfield M,
Frankel WN.
A curly-tail modifier locus, mct1, on mouse chromosome 17. Genomics 1995 Oct 10;29(3):719-24