Faculty Research 1990 - 1999
Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7.
Document Type
Article
Publication Date
1995
Keywords
Animal, Chromosome-Mapping, Chromosomes, Chromosomes-Human-Pair-15: ge, Human, Male, Membrane-Proteins: ge, Mice, Mice-Inbred-C57BL, Phosphoproteins: ge, Prader-Willi-Syndrome: ge, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S
First Page
594
Last Page
597
JAX Source
Genomics 1995 Dec 10;30(3):594-7
Abstract
The gene encoding the tight junction (zonula occludens) protein, TJP1, was mapped to human chromosome 15q13 by fluorescence in situ hybridization (FISH) using a cDNA probe. The Jackson Laboratory backcross DNA panel derived from the cross (C57BL/6JEi x SPRET/Ei) F1 females x SPRET/Ei males was used to map the mouse Tjp1 to chromosome 7 near position 30 on the Chromosome Committee Map, a region with conserved homology to human chromosome 15q13. FISH studies on metaphases from patients with the Prader-Willi (PWS) or the Angelman syndrome (AS) showed that TJP1 maps close but distal to the PWS/AS chromosome region.
Recommended Citation
Mohandas TK,
Chen XN,
Rowe LB,
Birkenmeier EH,
Fanning AS,
Anderson JM,
Korenberg JR.
Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7. Genomics 1995 Dec 10;30(3):594-7