Faculty Research 1990 - 1999


Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.

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Amino-Acid-Sequence, Animal, Cell-Lineage, Dwarfism-Pituitary: em, ge, DNA-Binding-Proteins: ge, Female, Gene-Expression, Homeodomain-Proteins: ge, ph, Hypothalamus: ph, Male, Mice, Mice-Inbred-C57BL, Molecular-Sequence-Data, Pituitary-Gland-Anterior: ab, em, ph, Point-Mutation, Sequence-Homology-Amino-Acid, Signal-Transduction, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Transcription-Factors: ge

JAX Source

Nature 1996 Nov 28;384(6607):327-33


The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.

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