Faculty Research 1990 - 1999
The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin.
Document Type
Article
Publication Date
1996
Keywords
Antigens-Thy-1, Biological-Markers, Bone-Marrow-Transplantation: im, Cell-Differentiation: im, Glucosephosphate-Isomerase, Lymphocyte-Count, Male, Mice, Mice-Inbred-C57BL, Mice-Mutant-Strains, Species-Specificity, Spleen: en, im, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocyte-Subsets: en, cl, tr
First Page
171
Last Page
176
JAX Source
Int Immunol 1996 Feb;8(2):171-6
Grant
DK25687/DK/NIDDK, HL46536/HL/NHLBI, CA60055/CA/NCI
Abstract
Donor and host T cells were distinguished by T cell antigen marker Thy-1 isotype and cytoplasmic isozyme Gpi-1 in this study of bone marrow transplantation between congenic mice. During the first 3-6 weeks after irradiation and marrow transfer, percentages of cells bearing the donor Thy-1 isotype in the periphery are much lower than percentages of T cells bearing the donor Gpi-1 marker. Apparently a population of Thy-1- donor T cells exists for several weeks after bone marrow transplantation. Further study showed that this population of CD3+, Thy-1- donor T cells expressed CD4+ or CD8+ and was found in peripheral blood and spleen but not in the thymus. This finding suggests their extrathymic origin.
Recommended Citation
Zhong RK,
Donnenberg AD,
Edison L,
Harrison DE.
The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin. Int Immunol 1996 Feb;8(2):171-6