Faculty Research 1990 - 1999
Effect of the mouse scid mutation on meiotic recombination.
Document Type
Article
Publication Date
1996
Keywords
Chromosome-Mapping, Crosses-Genetic, DNA-Satellite: an, ge, Female, Genetic-Markers, Genotype, Isoenzymes: an, ge, Linkage-(Genetics), Male, Meiosis, Mice, Mice-Inbred-BALB-C, Mice-Inbred-C57BL, Mice-SCID: ge, Polymerase-Chain-Reaction, Recombination-Genetic, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
497
Last Page
500
JAX Source
Mamm Genome 1996 Jul;7(7):497-500
Grant
RR01183/RR/NCRR, CA34196/CA/NCI, AI30389/AI/NIAID
Abstract
The goal of this study was to determine the effect of the mouse severe combined immunodeficiency (scid) mutation on the rate of meiotic recombination, by standard backcross linkage analysis. For this purpose, we examined four crosses that involved F1 hybrid animals heterozygous for the strain C57BL/6 and BALB/c genomes. In one set of reciprocal crosses, F1 animals were homozygous scid/scid, and in a second set of reciprocal crosses, F1 mice were homozygous wild-type (+/+) at the scid locus. Backcross progeny were typed for recombination between selected genetic markers on mouse Chromosomes (Chrs) 1, 4, 6, 7, 9, 15, and 17. Although some differences in recombination were observed over some intervals, the expression of the SCID phenotype did not appear to have a major or consistent effect on meiotic recombination.
Recommended Citation
Heine D,
Passmore HC,
Patel V,
Shultz LD,
Ward BP,
Cook SA,
Davisson MT.
Effect of the mouse scid mutation on meiotic recombination. Mamm Genome 1996 Jul;7(7):497-500