Faculty Research 1990 - 1999
A new MHC locus that influences class I peptide presentation.
Document Type
Article
Publication Date
1997
First Page
641
Last Page
651
JAX Source
Immunity 1997 Nov;7(5):641-51
Grant
R01DK47692/DK/NIDDK, R01AR38319/AR/NIAMS, R01AI28802/AI/NIAID
Abstract
We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human beta2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP, LMP, and tapasin. Identical findings in rats and mice, including identical HY peptide sequences and the failure of a rat Tap2A transgene to alter CTL recognition, suggest that a homologous locus with similar polymorphism exists in the rat. Cim2, or a closely linked locus, was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles. The data thus establish a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.
Recommended Citation
Simmons WA,
Roopenian DC,
Summerfield SG,
Jones RC,
Galocha B,
Christianson GJ,
Maika SD,
Zhou M,
Gaskell SJ,
Bordoli RS,
Ploegh HL,
Slaughter CA,
Lindahl KF,
Hammer RE,
Taurog JD.
A new MHC locus that influences class I peptide presentation. Immunity 1997 Nov;7(5):641-51