Faculty Research 1990 - 1999
A new MHC locus that influences class I peptide presentation.
Immunity 1997 Nov;7(5):641-51
R01DK47692/DK/NIDDK, R01AR38319/AR/NIAMS, R01AI28802/AI/NIAID
We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human beta2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP, LMP, and tapasin. Identical findings in rats and mice, including identical HY peptide sequences and the failure of a rat Tap2A transgene to alter CTL recognition, suggest that a homologous locus with similar polymorphism exists in the rat. Cim2, or a closely linked locus, was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles. The data thus establish a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.
Simmons, W A.; Roopenian, D C.; Summerfield, S G.; Jones, R C.; Galocha, B; Christianson, G J.; Maika, S D.; Zhou, M; Gaskell, S J.; Bordoli, R S.; Ploegh, H L.; Slaughter, C A.; Lindahl, K F.; Hammer, R E.; and Taurog, J D., " A new MHC locus that influences class I peptide presentation." (1997). Faculty Research 1990 - 1999. 922.