Faculty Research 1990 - 1999
High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase.
Document Type
Article
Publication Date
1997
Keywords
Aorta: pa, Atherosclerosis: bl, en, pa, Cholesterol, Diet-Atherogenic, Disease-Models-Animal, Female, Human, Lipids, Lipoproteins-HDL: bl, ph, Male, Mice, Mice-Transgenic, Phosphatidylcholine-Sterol-O-Acyltransferase: bi, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
744
Last Page
749
JAX Source
Nat Med 1997 Jul;3(7):744-9
Grant
HL30086/HL/NHLBI, HL32087/HL/NHLBI
Abstract
A subset of patients with high plasma HDL concentrations have enhanced rather than reduced atherosclerosis. We have developed a new transgenic mouse model overexpressing human lecithin-cholesteryl acyltransferase (LCAT) that has elevated HDL and increased diet-induced atherosclerosis. LCAT transgenic mouse HDLs are abnormal in both composition and function. Liver uptake of [3H]cholesteryl ether incorporated in transgenic mouse HDL was reduced by 41% compared with control HDL, indicating ineffective transport of HDL-cholesterol to the liver and impaired reverse cholesterol transport. Analysis of this LCAT-transgenic mouse model provides in vivo evidence for dysfunctional HDL as a potential mechanism leading to increased atherosclerosis in the presence of high plasma HDL levels.
Recommended Citation
Berard AM,
Foger B,
Remaley A,
Shamburek R,
Vaisman BL,
Talley G,
Paigen B,
Hoyt RF,
Marcovina S,
Brewer HB,
Santamarina FS.
High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase. Nat Med 1997 Jul;3(7):744-9