Faculty Research 1990 - 1999
Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex.
Document Type
Article
Publication Date
1997
Keywords
Amino-Acid-Sequence, Amino-Acid-Substitution, Animal, Base-Sequence, Chromosome-Mapping, Cloning-Molecular, DNA-Complementary: ge, Epitope-Mapping, H-2-Antigens: im, Hybrid-Cells, Mice, Mice-Inbred-BALB-C, Minor-Histocompatibility-Antigens: ge, im, Minor-Histocompatibility-Loci, Molecular-Sequence-Data, Peptides: im, Polymorphism-(Genetics), SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes-Cytotoxic: im
First Page
461
Last Page
472
JAX Source
Immunity 1997 Oct;7(4):461-72
Abstract
The products of minor histocompatibility (H) loci are serious barriers to tissue transplantation even among major histocompatibility complex (MHC) identical individuals, frequently causing chronic graft rejection and graft versus host disease. Over 50 minor H loci map to mouse autosomal chromosomes but none are known at the molecular level. By expression cloning, we identified the H13 locus, a classical minor H locus first detected 30 years ago by the trait of graft rejection. The H13a allele is located on chromosome 2 and encodes a novel protein that yields the rare naturally processed nonapeptide SSVVGVWYL (SVL9) for presentation by the Db MHC class I molecule. The SVL9 peptide binds Db MHC despite the absence of the consensus binding motif, and a conservative methyl group substitution (Valine 4 <--> Isoleucine) explains why reciprocal T cell responses are elicited in H13a and H13b congenic strains.
Recommended Citation
Mendoza LM,
Paz P,
Zuberi A,
Christianson G,
Roopenian DC,
Shastri N.
Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex. Immunity 1997 Oct;7(4):461-72