Id4 regulates neural progenitor proliferation and differentiation in vivo.
Document Type
Article
Publication Date
2004
Keywords
Brain, Cell-Differentiation, Cell-Proliferation, DNA-Binding-Proteins, G1-Phase, Inhibitor-of-Differentiation-Proteins, Mice, Mice-Knockout, Mutation, Neurons, S-Phase, Stem-Cells, Time-Factors, Transcription-Factors
First Page
5441
Last Page
5448
JAX Source
Development 2004 Nov; 131(21):5441-8.
Abstract
The mechanisms that determine whether a precursor cell re-enters the cell cycle or exits and differentiates are crucial in determining the types and numbers of cells that constitute a particular organ. Here, we report that Id4 is required for normal brain size, and regulates lateral expansion of the proliferative zone in the developing cortex and hippocampus. In its absence, proliferation of stem cells in the ventricular zone (VZ) is compromised. In early cortical progenitors, Id4 is required for the normal G1-S transition. By contrast, at later ages, ectopically positioned proliferating cells are found in the mantle zone of the Id4-/- cortex. These observations, together with evidence for the premature differentiation of early cortical stem cells, indicate that Id4 has a unique and complex function in regulating neural stem cell proliferation and differentiation.
Recommended Citation
Yun K,
Mantani A,
Garel S,
Rubenstein J,
Israel MA.
Id4 regulates neural progenitor proliferation and differentiation in vivo. Development 2004 Nov; 131(21):5441-8.