Mice mutant for ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile [In Process Citation]
Document Type
Article
Publication Date
2000
First Page
137
Last Page
140
JAX Source
Genesis 2000 Aug; 27(4):137-40.
Abstract
Summary: Phosphatidic acid phosphatases (PAPs) catalyze the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate and have been postulated to function both in lipid biosynthesis and in cellular signal transduction. In Drosophila melanogaster, the Type 2 phosphatidic acid phosphatase protein encoded by the wunen gene, negatively regulates primordial germ cell migration. We recently described the cloning and characterization of the mouse Ppap2c gene, which encodes the Type 2 phosphatidic acid phosphatase Pap2c (Zhang et al., Genomics 63:142-144). To analyze the in vivo role of the Ppap2c gene we constructed a null mutation by gene targeting. Ppap2c(-/-) homozygous mutant mice were viable, fertile, and exhibited no obvious phenotypic defects. These data demonstrate that the Ppap2c gene is not essential for embryonic development or fertility in mice. genesis 27:137-140, 2000.
Recommended Citation
Zhang N,
Sundberg JP,
Gridley T.
Mice mutant for ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile [In Process Citation] Genesis 2000 Aug; 27(4):137-40.