Bioinformatics toolbox for narrowing rodent quantitative trait loci.
Document Type
Article
Publication Date
2005
Keywords
Crosses-Genetic, Databases-Genetic, Genomics, Haplotypes, Humans, Mice, Quantitative-Trait-Loci, Rats
First Page
683
Last Page
692
JAX Source
Trends Genet 2005 Dec; 21(12):683-92.
Abstract
Quantitative trait locus (QTL) analysis is a powerful method for localizing disease genes, but identifying the causal gene remains difficult. Rodent models of disease facilitate QTL gene identification, and causal genes underlying rodent QTL are often associated with the corresponding human diseases. Recently developed bioinformatics methods, including comparative genomics, combined cross analysis, interval-specific and genome-wide haplotype analysis, followed by sequence and expression analysis, each facilitated by public databases, provide new tools for narrowing rodent QTLs. Here we discuss each tool, illustrate its application and generate a bioinformatics strategy for narrowing QTLs. Combining these bioinformatics tools with classical experimental methods should accelerate QTL gene identification.
Recommended Citation
DiPetrillo K,
Wang X,
Stylianou IM,
Paigen B.
Bioinformatics toolbox for narrowing rodent quantitative trait loci. Trends Genet 2005 Dec; 21(12):683-92.