Genealogies of mouse inbred strains.
Document Type
Article
Publication Date
2000
Keywords
Databases-Factual, Disease-Models-Animal, Human, Internet, Mice, Mice-Inbred-Strains, Phenotype, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
23
Last Page
25
JAX Source
Nat Genet 2000 Jan; 24(1):23-5.
Grant
HG00330/HG/NHGRI
Abstract
The mouse is a prime organism of choice for modelling human disease. Over 450 inbred strains of mice have been described, providing a wealth of different genotypes and phenotypes for genetic and other studies. As new strains are generated and others become extinct, it is useful to review periodically what strains are available and how they are related to each other, particularly in the light of available DNA polymorphism data from microsatellite and other markers. We describe the origins and relationships of inbred mouse strains, 90 years after the generation of the first inbred strain. Given the large collection of inbred strains available, and that published information on these strains is incomplete, we propose that all genealogical and genetic data on inbred strains be submitted to a common electronic database to ensure this valuable information resource is preserved and used efficiently.
Recommended Citation
Beck JA,
Lloyd S,
Hafezparast M,
Lennon PM,
Eppig JT,
Festing MF,
Fisher EM.
Genealogies of mouse inbred strains. Nat Genet 2000 Jan; 24(1):23-5.