The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs.
Document Type
Article
Publication Date
2000
Keywords
Female, Genes, Human, Linkage-Disequilibrium, Male, Mutagenesis, Phenotype, Quantitative-Trait, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)
First Page
381
Last Page
384
JAX Source
Nat Genet 2000 Aug; 25(4):381-4.
Grant
HL58982/HL/NHLBI, CA75056/CA/NCI, RR12305/RR/NCRR
Abstract
In model organisms, chemical mutagenesis provides a powerful alternative to natural, polygenic variation (for example, quantitative trait loci (QTLs)) for identifying functional pathways and complex disease genes. Despite recent progress in QTLs, we expect that mutagenesis is will ultimately prove more effective because the prospects of gene identification are high and every gene affecting a trait is potentially a target.
Recommended Citation
Nadeau JH,
Frankel WN.
The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. Nat Genet 2000 Aug; 25(4):381-4.