Discovery of biological networks from diverse functional genomic data.
Document Type
Article
Publication Date
2005
Keywords
Cell-Cycle-Proteins, Computational-Biology, Computer-Graphics, Genomics, HSP90-Heat-Shock-Proteins, Molecular-Chaperones, Protein-Interaction-Mapping, Reproducibility-of-Results, Saccharomyces-cerevisiae, Saccharomyces-cerevisiae-Proteins
JAX Source
Genome Biol 2005; 6(13):R114.
Abstract
We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.
Recommended Citation
Myers CL,
Robson D,
Wible A,
Hibbs MA,
Chiriac C,
Theesfeld CL,
Dolinski K,
Troyanskaya OG.
Discovery of biological networks from diverse functional genomic data. Genome Biol 2005; 6(13):R114.