Mouse models as a tool to unravel the genetic basis for human otitis media.
Document Type
Article
Publication Date
2006
Keywords
Disease-Models-Animal, Humans, Otitis-Media
First Page
9
Last Page
15
JAX Source
Brain Res 2006 May; 1091(1):9-15.
Abstract
The pathogenesis of otitis media (OM) is multifactorial and includes infection, anatomical factors, immunologic status, genetic predisposition, and environmental factors. OM remains the most common cause of hearing impairment in childhood. Genetic predisposition is increasingly recognized as an important factor. The completion of the mouse genome sequence has offered a powerful basket of tools for investigating gene function and can expect to generate a rich resource of mouse mutants for the elucidation of genetic factors underlying OM. We review the literature and discuss recent progresses in developing mouse models and using mouse models to uncover the genetic basis for human OM.
Recommended Citation
Zheng QY,
Hardisty HR,
Brown SD.
Mouse models as a tool to unravel the genetic basis for human otitis media. Brain Res 2006 May; 1091(1):9-15.