Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.
Document Type
Article
Publication Date
2007
Keywords
Antigens-CD8, Autoantigens, Diabetes-Mellitus-Type-1, Disease-Models-Animal, Epitopes, Glucose-6-Phosphatase, Humans, Islets-of-Langerhans, Mice, Proteins
First Page
192
Last Page
195
JAX Location
see Reprint Collection or Book Collection W1 AN626YL v.1103 2007
JAX Source
Ann N Y Acad Sci 2007; 1103:192-5
Abstract
Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin-producing beta cells by autoreactive T cells. CD8(+) T cells play an essential role in this beta cell destruction. However, little is known about the target antigens of CD8(+) T cells in human T1D patients. The aim of this study was to assess whether an epitope derived from the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), IGRP(265-273,) which has recently been identified as a target in non-obese diabetic (NOD) mice and is fully homologous to the human epitope, is a target of human diabetogenic CD8(+) T cells. We isolated a human CD8 T cell clone against this epitope, which confirms that this IGRP epitope is shared across species.
Recommended Citation
Unger WW,
Pinkse GG,
Mulder vd,
van dA,
Kester MG,
Ossendorp F,
Drijfhout JW,
Serreze DV,
Roep BO.
Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men. Ann N Y Acad Sci 2007; 1103:192-5