Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.
Antigens-CD8, Autoantigens, Diabetes-Mellitus-Type-1, Disease-Models-Animal, Epitopes, Glucose-6-Phosphatase, Humans, Islets-of-Langerhans, Mice, Proteins
see Reprint Collection or Book Collection W1 AN626YL v.1103 2007
Ann N Y Acad Sci 2007; 1103:192-5
Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin-producing beta cells by autoreactive T cells. CD8(+) T cells play an essential role in this beta cell destruction. However, little is known about the target antigens of CD8(+) T cells in human T1D patients. The aim of this study was to assess whether an epitope derived from the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), IGRP(265-273,) which has recently been identified as a target in non-obese diabetic (NOD) mice and is fully homologous to the human epitope, is a target of human diabetogenic CD8(+) T cells. We isolated a human CD8 T cell clone against this epitope, which confirms that this IGRP epitope is shared across species.
Unger, W W.; Pinkse, G G.; Mulder, van der Kracht; van, der Slik A.; Kester, M G.; Ossendorp, F; Drijfhout, J W.; Serreze, D V.; and Roep, B O., "Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men." (2007). Faculty Research 2000 - 2009. 1541.