Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex.
Document Type
Article
Publication Date
2007
Keywords
Binding-Sites, Chromosome-Mapping, Cytoplasm, Genes-MHC-Class-II, Hematopoietic-Stem-Cells, Humans, Immunohistochemistry, Molecular-Chaperones, Molecular-Sequence-Data, Neoplasms, Protein-Conformation, Tumor-Cells-Cultured
First Page
181
Last Page
188
JAX Location
see Reprint Collection (a pdf is available)
JAX Source
Tissue Antigens 2007 Feb; 69(2):181-8.
Abstract
Genes at the centromeric end of the human leukocyte antigen region influence adaptive autoimmune diseases and cancer. In this study, we characterized protein expression of HKE2, a gene located in the centromeric portion of the class II region of the major histocompatibility complex encoding subunit 6 of prefoldin. Immunohistochemical analysis using an anti-HKE2 antibody indicated that HKE2 protein expression is dramatically upregulated as a consequence of activation. In a tissue microarray and in several tumors, HKE2 was overexpressed in certain cancers compared with normal counterparts. The localization of the HKE2 gene to the class II region, its cytoplasmic expression and putative protein-binding domain suggest that HKE2 may function in adaptive immunity and cancer.
Recommended Citation
Ostrov DA,
Barnes CL,
Smith LE,
Binns S,
Brusko TM,
Brown AC,
Quint PS,
Litherland SA,
Roopenian DC,
Iczkowski KA.
Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. Tissue Antigens 2007 Feb; 69(2):181-8.