On the subspecific origin of the laboratory mouse.
Document Type
Article
Publication Date
2007
Keywords
Chromosomes-Mammalian, Evolution-Molecular, Genetic-Speciation, Genome, Mice-Inbred-Strains, Phylogeny, Polymorphism-Single-Nucleotide
First Page
1100
Last Page
1107
JAX Source
Nat Genet 2007 Sep; 39(9):1100-7.
Abstract
The genome of the laboratory mouse is thought to be a mosaic of regions with distinct subspecific origins. We have developed a high-resolution map of the origin of the laboratory mouse by generating 25,400 phylogenetic trees at 100-kb intervals spanning the genome. On average, 92% of the genome is of Mus musculus domesticus origin, and the distribution of diversity is markedly nonrandom among the chromosomes. There are large regions of extremely low diversity, which represent blind spots for studies of natural variation and complex traits, and hot spots of diversity. In contrast with the mosaic model, we found that most of the genome has intermediate levels of variation of intrasubspecific origin. Finally, mouse strains derived from the wild that are supposed to represent different mouse subspecies show substantial intersubspecific introgression, which has strong implications for evolutionary studies that assume these are pure representatives of a given subspecies.
Recommended Citation
Yang H,
Bell TA,
Churchill GA,
Pardo Md.
On the subspecific origin of the laboratory mouse. Nat Genet 2007 Sep; 39(9):1100-7.