Notch signaling in vascular development and physiology.
Document Type
Article
Publication Date
2007
Keywords
Arteries, Blood-Vessels, CADASIL, Cardiovascular-Diseases, Cell-Differentiation, Endothelial-Cells, Humans, Models-Biological, Muscle-Smooth-Vascular, Neoplasms-Vascular-Tissue, Neovascularization-Pathologic, Receptors-Notch, Signal-Transduction, Veins
First Page
2709
Last Page
2718
JAX Source
Development 2007 Aug; 134(15):2709-18.
Abstract
Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include regulation of artery/vein differentiation in endothelial and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during both normal development and tumor angiogenesis, and the differentiation and physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular and cardiovascular diseases. In this review, I summarize recent findings and discuss the growing relevance of Notch pathway modulation for therapeutic applications in disease.
Recommended Citation
Gridley T.
Notch signaling in vascular development and physiology. Development 2007 Aug; 134(15):2709-18.