Gene Ontology annotations: what they mean and where they come from.
Document Type
Article
Publication Date
2008
Keywords
Artificial-Intelligence, Computational-Biology, Database-Management-Systems, Databases-Genetic, Genomics, Humans, Models-Biological, Pattern-Recognition-Automated, Semantics, Systems-Integration, User-Computer-Interface, Vocabulary-Controlled
JAX Source
BMC Bioinformatics 2008; 9(Suppl 5):S2.
Abstract
To address the challenges of information integration and retrieval, the computational genomics community increasingly has come to rely on the methodology of creating annotations of scientific literature using terms from controlled structured vocabularies such as the Gene Ontology (GO). Here we address the question of what such annotations signify and of how they are created by working biologists. Our goal is to promote a better understanding of how the results of experiments are captured in annotations, in the hope that this will lead both to better representations of biological reality through annotation and ontology development and to more informed use of GO resources by experimental scientists.
Recommended Citation
Hill DP,
Smith B,
McAndrews HM,
Blake JA.
Gene Ontology annotations: what they mean and where they come from. BMC Bioinformatics 2008; 9(Suppl 5):S2.