Dependence of antibody-mediated presentation of antigen on FcRn.
Document Type
Article
Publication Date
2008
Keywords
Antigen-Presentation, Antigen-Antibody-Complex, Antigen-Presenting-Cells, Cell-Proliferation, Dendritic-Cells, Hematopoietic-System, Hemocyanin, Histocompatibility-Antigens-Class-I, Humans, Immunoglobulin-G, Ligands, Lysosome-Associated-Membrane-Glycoproteins, Lysosomes, Mice, Monocytes, Mutation, Protein-Binding, Protein-Processing-Post-Translational, Protein-Transport, Receptors-Fc, T-Lymphocytes
First Page
9337
Last Page
9342
JAX Source
Proc Natl Acad Sci U S A 2008 Jul; 105(27):9337-42.
Abstract
The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.
Recommended Citation
Qiao SW,
Kobayashi K,
Johansen FE,
Sollid LM,
Andersen JT,
Milford E,
Roopenian DC,
Lencer WI,
Blumberg RS.
Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A 2008 Jul; 105(27):9337-42.