Marrow fat and the bone microenvironment: developmental, functional, and pathological implications.
Document Type
Article
Publication Date
2009
Keywords
Animals, Bone-Marrow, Humans, Mesenchymal-Stem-Cells, Mice, Models-Biological, Osteoblasts, Osteoporosis, PPAR-gamma
First Page
109
Last Page
124
JAX Location
see Reprint Collection (a pdf is available)
JAX Source
Crit Rev Eukaryot Gene Expr 2009; 19(2):109-24.
Abstract
Bone marrow adipogenesis is a normal physiologic process in all mammals. However, its function is unknown. The mesenchymal stem cell is the marrow precursor for adipocytes as well as osteoblasts, and PPARG is an essential differentiation factor for entrance into the fat lineage. Mouse models have provided significant insight into the molecular cues that define stromal cell fate. In humans, accelerated marrow adipogenesis has been associated with aging and several chronic conditions, including diabetes mellitus and osteoporosis. Newer imaging techniques have been used to determine the developmental time course of fat generation in bone marrow. However, more studies are needed to understand the interrelationship among hematopoietic, osteoblastic, and adipogenic cells within the marrow niche.
Recommended Citation
Rosen CJ,
Ackert BC,
Rodriguez JP,
Pino AM.
Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr 2009; 19(2):109-24.