Insulin-like growth factor-I and bone: lessons from mice and men.
Document Type
Article
Publication Date
2009
Keywords
Bone-Remodeling, Bone-and-Bones, Humans, Insulin-Like-Growth-Factor-I, Mice, Osteogenesis, Signal-Transduction
First Page
1277
Last Page
1285
JAX Location
see Reprint Collection (a pdf is available)
JAX Source
Pediatr Nephrol 2009 Jul; 24(7):1277-85.
Abstract
Studies of humans and animals have illustrated a strong association between insulin-like growth factor (IGF)-I and skeletal acquisition. However, the precise molecular and cellular mechanisms underlying this effect still largely remain unknown. Recent advances in molecular and genetic techniques for in vivo studies provide excellent tools for us to explore how circulating and skeletal insulin-like growth factor-I (IGF-I) may affect not only peak bone mass but also bone loss. This review highlights recent findings that shed new light on the interaction of the IGF-I signaling pathway with other skeletal networks, and the role of IGF-I in the bone marrow milieu.
Recommended Citation
Kawai M,
Rosen CJ.
Insulin-like growth factor-I and bone: lessons from mice and men. Pediatr Nephrol 2009 Jul; 24(7):1277-85.