Quantitative trait locus analysis using J/qtl.

Document Type

Article

Publication Date

2009

Keywords

Animals, Chromosome-Mapping, Humans, Quality-Control, Quantitative-Trait-Loci, Regression-Analysis

First Page

175

Last Page

188

JAX Location

see Reprint Collection (a pdf is available)

JAX Source

Methods Mol Biol 2009; 573:175-88.

Abstract

Quantitative trait locus (QTL) analysis is a statistical method to link phenotypes with regions of the genome that affect the phenotypes in a mapping population. R/qtl is a powerful statistical program commonly used for analyzing rodent QTL crosses, but R/qtl is a command line program that can be difficult for novice users to run. J/qtl was developed as an R/qtl graphical user interface that enables even novice users to utilize R/qtl for QTL analyses. In this chapter, we describe the process for analyzing rodent cross data with J/qtl, including data formatting, data quality control, main scan QTL analysis, pair scan QTL analysis, and multiple regression modeling; this information should enable new users to identify QTL affecting phenotypes of interest within their rodent cross datasets.

Please contact the Joan Staats Library for information regarding this document.

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