Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss.
Document Type
Article
Publication Date
2009
Keywords
Bone-Density-Conservation-Agents, Bone-Remodeling, Female, Fractures-Spontaneous, Humans, Osteoporosis-Postmenopausal, Perimenopause, Risk-Assessment
First Page
118
Last Page
126
JAX Location
see Reprint Collection (a pdf is available).
JAX Source
Curr Osteoporos Rep 2009 Dec; 7(4):118-26.
Abstract
Recent reports suggest that bone loss begins during late perimenopause at a dramatic rate, even before estrogen levels plummet. During the ensuing 5 years, there is evidence of the beginnings of microarchitectural deterioration, which impacts bone strength and ultimately enhances its propensity to fracture. The diagnosis of osteoporosis based on T-scores alone, or through stratification for a high fracture risk by FRAX, excludes these women who are rapidly losing bone. Because all antiosteoporosis therapies, in particular bisphosphonates, reduce bone loss, we propose aggressive, likely short-term therapy with a goal to reduce bone loss, stabilize bone density, and prevent microarchitectural deterioration.
Recommended Citation
Zaidi M,
Turner CH,
Canalis E,
Pacifici R,
Sun L,
Iqbal J,
Guo XE,
Silverman S,
Epstein S,
Rosen CJ.
Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss. Curr Osteoporos Rep 2009 Dec; 7(4):118-26.