High-resolution genetic and physical mapping of modifier-of-deafwaddler (mdfw) and Waltzer (Cdh23v).

Document Type

Article

Publication Date

2001

Keywords

Animal, Chromosome-Mapping, Contig-Mapping, Deafness, Female, Genes-Recessive, Haplotypes, Hearing, Male, Mice, Mice-Mutant-Strains, Mutation, Phenotype, Physical-Chromosome-Mapping, Polymorphism-(Genetics), Radiation-Hybrid-Mapping, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

First Page

338

Last Page

342

JAX Source

Genomics 2001 May 1;73(3):338-42.

Grant

DC03611/DC/NIDCD, DC03771/DC/NIDCD, NS31348/NS/NINDS, Z01DC00036-02/DC/NIDCD

Abstract

Modifier-of-deafwaddler (mdfw) and waltzer (Cdh23v) are loci on mouse chromosome 10 encoding factors that are essential for the function of auditory hair cells. The BALB/cByJ-specific mdfw allele encodes a necessary and sufficient modifier that induces progressive early onset hearing loss in CBy-dfw2J heterozygotes. Recessive mutations in the waltzer locus result in circling behavior and congenital deafness. In this report we present a high-resolution integrated genetic and physical map of mdfw and Cdh23(v). Our genetic analyses localize mdfw between markers D10Mit60 and 148M13T7 within a 1.01-cM region. The Cdh23v critical interval is fully contained within the mdfw region and localizes between markers 146O23T7 and 148M13T7 within a 0.35-cM interval that is represented in an approximately 500-kb BAC contig. Our data suggest that mdfw and Cdh23v are allelic. Copyright 2001 Academic Press.

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