Genetic analysis of a new mouse model for non-insulin-dependent diabetes.
Document Type
Article
Publication Date
2001
Keywords
Chromosome-Mapping, Crosses-Genetic, Diabetes-Mellitus-Non-Insulin-Dependent, Disease-Models-Animal, Female, Genetic-Predisposition-to-Disease, Genome, Hyperglycemia, Hyperlipidemia, Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-Strains, Obesity, Quantitative-Trait, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
273
Last Page
286
JAX Source
Genomics 2001 Jun; 74(3):273-86.
Grant
CA34196/CA/NCI, DK46977/DK/NIDDK
Abstract
The TallyHo (TH) mouse strain is a newly established model for non-insulin-dependent diabetes mellitus (NIDDM). TH mice show obesity, hyperinsulinemia, hyperlipidemia, and male-limited hyperglycemia. A genetic dissection of the diabetes syndrome has been carried out using male backcross 1 progeny obtained from crosses between (C57BL/6J x TH)F1 and TH mice or (CAST/Ei x TH)F1 and TH mice. A genome-wide scan reveals three quantitative trait loci (QTLs), Tanidd1-3 (TH-associated NIDDM) linked to hyperglycemia. The major QTL (common in both crosses), Tanidd1, maps to chromosome (Chr) 19. Additionally, gene-gene interactions contributing to hyperglycemia have been observed between Tanidd1 and a locus on Chr 18 as well as between Tanidd2 and a locus on Chr 16. The overt hyperglycemia in TH mice is, therefore, likely due to a mutation in a major diabetes susceptibility locus on Chr 19, which interacts with additional genes to lead to an observable phenotype. Copyright 2001 Academic Press.
Recommended Citation
Kim JH,
Sen S,
Avery CS,
Simpson E,
Chandler P,
Nishina PM,
Churchill GA,
Naggert JK.
Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics 2001 Jun; 74(3):273-86.