The nude mouse skin phenotype: the role of Foxn1 in hair follicle development and cycling.
Document Type
Article
Publication Date
2001
Keywords
Hair-Follicle, Male, Mice, Mice-Inbred-BALB-C, Mice-Inbred-HRS, Regeneration, Skin, Transcription-Factors
First Page
171
Last Page
178
JAX Source
Exp Mol Pathol 2001 Oct; 71:171-178.
Abstract
The original nude mouse mutation has proven to be an incredibly valuable biomedical tool since its discovery in 1966. Initially its value was as a tool to study the immune system. The immunodeficiency in this mutant mouse made nude mice valuable as hosts for xenografts, primarily for cancer research. More recently, the most obvious clinical feature of this mutant mouse, lack of hair, has been capitalized on to define the role of Foxn1 in normal and pathological skin and hair follicle physiology.
Recommended Citation
Mecklenburg L,
Nakamura M,
Sundberg JP,
Paus R.
The nude mouse skin phenotype: the role of Foxn1 in hair follicle development and cycling. Exp Mol Pathol 2001 Oct; 71:171-178.