Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues.
Document Type
Article
Publication Date
2002
Keywords
Animal, B-Lymphocytes, Chemokines, Dendritic-Cells-Follicular, Erythrocytes, Genes-RAG-1, Immunoglobulin-G, Lymph-Nodes, Lymphoid-Tissue, Lymphotoxin, Membrane-Proteins, Mice, Mice-Inbred-C57BL, Mice-Knockout, Mice-SCID, Peyer's-Patches, Sheep, Spleen, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Tetradecanoylphorbol-Acetate
First Page
239
Last Page
250
JAX Source
Immunity 2002 Sep; 17:239-50.
Grant
CA65795/CA/NCI, N01-CO-12400/CO/NCI
Abstract
In order to definitively ascertain the functional contribution of lymphotoxin (LT) expressed by B cells, we produced mice with the LTbeta gene deleted from B cells (B-LTbeta KO mice). In contrast to systemic LTbeta deletion, in B-LTbeta KO mice only splenic microarchitecture was affected, while lymph nodes and Peyer's patches (PP) were normal, except for PP's reduced size. Even though B-LTbeta KO spleens retained a small number of follicular dendritic cells (FDC) which appeared to be dependent on LTbeta produced by T cells, IgG responses to sheep red blood cells were markedly reduced. Thus, the organogenic function of B-LTbeta is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response.
Recommended Citation
Tumanov A,
Kuprash D,
Lagarkova M,
Grivennikov S,
Abe K,
Shakhov A,
Drutskaya L,
Stewart C,
Chervonsky A,
Nedospasov S.
Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 2002 Sep; 17:239-50.