Cloning and genomic characterization of Felis domesticus papillomavirus type 1.
Document Type
Article
Publication Date
2002
Keywords
Base-Sequence, Cat-Diseases, Cats, Cloning-Molecular, DNA-Viral, Evolution, Genes-Viral, Genome-Viral, Human, Molecular-Sequence-Data, Open-Reading-Frames, Papillomavirus, Papillomavirus-Infections, Phylogeny, Regulatory-Sequences-Nucleic-Acid, Sequence-Homology-Nucleic-Acid, SUPPORT-NON-U-S-GOVT, Tumor-Virus-Infections
First Page
313
Last Page
321
JAX Source
Virology 2002 Sep 30; 301(2):313-321.
Abstract
A novel papillomavirus was cloned from hyperkeratotic cutaneous lesions of a Persian domestic cat. The Felis domesticus papillomavirus (FdPV-1) genome counts 8300 bp and has a typical genome structure with an early region (E1, E2, E4, E6, E7), a late region (L1, L2), and a noncoding upstream regulatory region (URR or NCR1) between the end of L1 and the beginning of E6. The FdPV-1 also shows an unusual second noncoding region (NCR2) of 1.3 kb, situated between the end of E2 and the beginning of L2. This NCR2 is uniquely related to a similar region in the canine oral papillomavirus (COPV). Phylogenetic analysis places FdPV-1 together with COPV, the cottontail rabbit papillomavirus, human papillomavirus type 1 (HPV-1), and HPV-63 in the group of the benign cutaneous papillomaviruses. The position of FdPV-1 in the phylogenetic tree allows us to hypothesize that already in an early phase of the papillomavirus molecular evolution, a split occurred into viruses with a dual tropism primarily for cutaneous epithelia but also secondarily for mucosal surfaces, and viruses with a specific monotropism for mucosal surfaces. The close relationship between FdPV-1 and COPV, and between their Canidae and Felidae hosts, supports the hypothesis that papillomaviruses have speciated and coevolved together with their hosts throughout vertebrate evolution. A papillomavirus mutation rate of 0.73 to 0.96 x 10(-8) nucleotide substitutions per base per year was calculated.
Recommended Citation
Tachezy R,
Duson G,
Rector A,
Jenson AB,
Sundberg JP,
Van RM.
Cloning and genomic characterization of Felis domesticus papillomavirus type 1. Virology 2002 Sep 30; 301(2):313-321.