PPARdelta is a very low-density lipoprotein sensor in macrophages.
Document Type
Article
Publication Date
2003
Keywords
Alleles, Animal, Blotting-Northern, Dose-Response-Relationship-Drug, Flow-Cytometry, Genes-Reporter, Genetic-Vectors, Lipids, Lipoproteins-VLDL, Macrophages, Mice, Models-Genetic, Oxygen, Point-Mutation, Promoter-Regions-(Genetics), Receptors-Cytoplasmic-and-Nuclear, Signal-Transduction, Time-Factors, Transcription-Factors, Transcription-Genetic, Transfection
First Page
1268
Last Page
1273
JAX Source
Proc Natl Acad Sci U S A 2003 Feb; 100(3):1268-73.
Abstract
Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor delta. The signaling components of native VLDL are its triglycerides, whose activity is enhanced by lipoprotein" lipase. Generation of peroxisome proliferator-activated receptor delta null macrophages verifies the absolute requirement of this transcription factor in mediating the VLDL response. Thus, our data reveal a pathway through which dietary triglycerides and VLDL can directly regulate gene expression in atherosclerotic lesions.
Recommended Citation
Chawla A,
Lee CH,
Barak Y,
He W,
Rosenfeld J,
Liao D,
Han J,
Kang H,
Evans RM.
PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A 2003 Feb; 100(3):1268-73.