Acoustic startle and prepulse inhibition in 40 inbred strains of mice.
Document Type
Article
Publication Date
2003
Keywords
Animal, Comparative-Study, Female, Male, Mice, Mice-Inbred-Strains, Phenotype, Reference-Values, Startle-Reaction
First Page
716
Last Page
727
JAX Location
see Reprint Collection
JAX Source
Behav Neurosci 2003 Aug; 117(4):716-27.
Abstract
A high-throughput phenotype screening protocol was used to measure the acoustic startle response (ASR) and prepulse inhibition (PPI) in mice. ASRs were evoked by noise bursts; prepulses for PPI were 70 dB sound pressure level tones of 4, 12, and 20 kHz. Forty inbred strains of mice were tested (in most cases using 10 males and 10 females of each strain). The data on both the ASR and PPI had high internal and test-retest reliability and showed large differences among inbred strains, indicative of strong genetic influences. Previously obtained measures of hearing sensitivity in the same inbred strains were not significantly correlated with ASR or PPI measures.
Recommended Citation
Willott JF,
Tanner L,
O'Steen J,
Johnson KR,
Bogue MA,
Gagnon L.
Acoustic startle and prepulse inhibition in 40 inbred strains of mice. Behav Neurosci 2003 Aug; 117(4):716-27.