Homologous recombinational repair proteins in mouse meiosis.
Document Type
Article
Publication Date
2004
First Page
191
Last Page
200
JAX Source
Cytogenet Genome Res 2004; 107(3-4):191-200.
Abstract
Eukaryotic meiotic recombination requires numerous biochemical processes, including break initiation, end resection, strand invasion and heteroduplex formation, and, finally, crossover resolution. In this review, we discuss primarily those proteins involved in the initial stages of homologous recombination, including SPO11, MRE11, RAD50, NBS1, DMC1, RAD51, RAD51 paralogs, RAD52, RPA, RAD54, and RAD54B. Focusing on the mouse as a model organism, we discuss what is known about the conserved roles of these proteins in vertebrate somatic cells and in mammalian meiosis. We consider such information as gene expression in gonadal tissue, protein localization patterns on chromosomal cores in meiocyte nuclei, and information gleaned from mouse models.
Recommended Citation
Bannister LA,
Schimenti JC.
Homologous recombinational repair proteins in mouse meiosis. Cytogenet Genome Res 2004; 107(3-4):191-200.