The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.
Document Type
Article
Publication Date
2004
Keywords
Animals, Expressed-Sequence-Tags, Female, Granulosa-Cells, Heterotrimeric-GTP-Binding-Proteins, In-Situ-Hybridization, Ligands, Luteinizing-Hormone, Meiosis, Metaphase, Mice, Mice-Inbred-C57BL, Mice-Knockout, Mitosis, Oocytes, Ovarian-Follicle, Proteochondroitin-Sulfates, RNA, Receptors-G-Protein-Coupled
First Page
1947
Last Page
1950
JAX Source
Science 2004 Dec; 306(5703):1947-50.
Abstract
Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding somatic cells. Here we show that the orphan Gs-linked receptor GPR3, which is localized in the oocyte, maintains this arrest. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes. Thus, the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis.
Recommended Citation
Mehlmann LM,
Saeki Y,
Tanaka S,
Brennan TJ,
Evsikov AV,
Pendola FL,
Knowles BB,
Eppig JJ,
Jaffe LA.
The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science 2004 Dec; 306(5703):1947-50.